The Krishna river is held in reverence by all Hindus and a ritual dip in the river is believed to purify the mortals. The river is personified as the Goddess Krishnaveni mata.
Many pilgrim centres including the Mallikarjuna temple (Srisailam), Amareshwara swamy temple (Amaravati) and the Durga-Malleshwara temple (Vijayawada) flourish along the course of the river. These centres attract thousands of devotees. The Krishna Pushkaram fair is held on the banks of the river once in twelve years.